"README" file for installation of NEURON under MSWindows This will install the MSWindows version of the NEURON simulation environment on your hard disk. The core source code for this software is identical with the UNIX/Linux version, which is available over the WWW. Please read the following information before proceeding further. ======================================================== REQUIREMENTS 1. 386 or above running MSWindows 3.1 or above. 2. At least 8MB of RAM. If you compile biophysical mechanisms, gcc is pretty slow with 8MB RAM due to swapping. 3. 10MB disk space (20MB if you install the portion that compiles biophysical mechanisms and creates DLLs). 4. If you are using MSWindows 3.1, you will also need win32s. After the installation program has exited, be sure to read the topic "Completing installation" at the beginning of the NOTES file ($(NEURONHOME)/notes.txt). ======================================================== UNINSTALLING PRIOR VERSIONS Before installing a new version of NEURON, it is probably a good idea to uninstall your old version. Win 95/98/NT users can use Add/Remove Programs in the Control Panel to uninstall NEURON v.4.2b and later. Earlier versions can be uninstalled by following these steps: 1. Remove the directory created by the install program where the NEURON software resides. This will free a good deal of disk space. 2. Remove the NEURON program group. 3. Edit the win.ini file and remove the [INTERVIEWS] and [NEURON] sections. 4. Edit the autoexec.bat file and remove the NEURONHOME and DJGENV environment variables. Also eliminate the old NEURON directory from the PATH. 5. Remove (or return to its original state) the shell command in config.sys (prior NEURON installations may have increased the environment size to 5000). ======================================================== INSTALLATION UNDER MSWin 95/98/NT 1. Open the Control Panel and click on the Add/Remove Programs icon. 2. Follow the setup instructions that appear on the screen. You will be offered these three alternatives: Typical installation installs NEURON, the on-line help files, and the NMODL compiler. Minimum installation installs only NEURON's core files, so you can run simulations. If you later decide to put the help files on your PC, or want to create your own biophysical mechanisms, you can add these components with the Custom installation. Custom installation lets you install just those components that you select. Please note that the NMODL compiler requires the presence of NEURON's core files. 3. When the installer has finished, please be sure to read $(NEURONHOME)/notes.txt, especially the topic "Completing installation." ======================================================== USER-DEFINED MEMBRANE MECHANISMS If you wish use the model description language to write your own membrane mechanisms, you will need the NMODL compiler to turn them into a DLL that will be dynamically loaded into neuron.exe. You do not have to install the NMODL compiler if you already have a DLL file that contains the desired mechanisms. The NMODL compiler requires a preexisting installation of NEURON. After installation, read the NOTES and README files in the $(NEURONHOME)/djg subdirectory. ======================================================== WWW BROWSERS You can configure your browser to use NEURON as a "helper program." This will let hypertext links bring up dynamic simulations. For further information see $(NEURONHOME)/notes.txt