cells don't fire without axon
Posted: Fri Feb 24, 2023 9:17 pm
hello
I am using a L23 pyramidal neuron from the HBP cortical microcircuit, Aberra et al 2018 https://senselab.med.yale.edu/ModelDB/S ... del=241165. I replace the morphology of a L23 cortical cell with my own morphology, but I preserve mechnanisms and synapse distribution from the HBP. If I use soleley the dendritic arborization the cells don't fire, however if I add an axon the cells do fire. As I currently do not have complete axonal reconsrucions at my disposal I would prefer not to use an axon. From previous experience with other models I've seen that neuronal models do fire without modelling of the axon. How can make my model fire in the absence of an axonal reconsruction, or do I sill need even a simple one?
In that case, what is the easiest solution to my problem? I would be looking for a simple axonal structure in the format of "swc" but so far I have only found more complex "hoc" axonal reconsructions in MODELDB.
thank you,
Alexandra
I am using a L23 pyramidal neuron from the HBP cortical microcircuit, Aberra et al 2018 https://senselab.med.yale.edu/ModelDB/S ... del=241165. I replace the morphology of a L23 cortical cell with my own morphology, but I preserve mechnanisms and synapse distribution from the HBP. If I use soleley the dendritic arborization the cells don't fire, however if I add an axon the cells do fire. As I currently do not have complete axonal reconsrucions at my disposal I would prefer not to use an axon. From previous experience with other models I've seen that neuronal models do fire without modelling of the axon. How can make my model fire in the absence of an axonal reconsruction, or do I sill need even a simple one?
In that case, what is the easiest solution to my problem? I would be looking for a simple axonal structure in the format of "swc" but so far I have only found more complex "hoc" axonal reconsructions in MODELDB.
thank you,
Alexandra