Rm alteration for myelin modeling
Posted: Wed May 03, 2017 8:44 am
Dear all,
I was wondering: how can one incorporate the membrane resistance (Rm, [ohm-cm^2]) of a section into Neuron?
I am modeling myelin, and the Rm and Cm (membrane capacitance) are both changing in the myelinated sections, from the values of the non-myelinated axon. However, nowhere in Neuron is to be found a way to change this Rm. I am keeping the diameter of the myelinated section similar to the bare axon's diameter.
Could this be done via changing the axial resistivity (Ra, [ohm-cm]) and the constant lambda (λ)?
I found the equation: λ = (sqrt((Rm*d)/Ra))/2 (source: http://www.columbia.edu/cu/biology/cour ... cture5.pdf)
Hence: Ra = (Rm*diameter)/(4*(λ^2)).
Is this legit to use like that? Can one alter it via another property maybe?
Thank you very much!
Best,
I was wondering: how can one incorporate the membrane resistance (Rm, [ohm-cm^2]) of a section into Neuron?
I am modeling myelin, and the Rm and Cm (membrane capacitance) are both changing in the myelinated sections, from the values of the non-myelinated axon. However, nowhere in Neuron is to be found a way to change this Rm. I am keeping the diameter of the myelinated section similar to the bare axon's diameter.
Could this be done via changing the axial resistivity (Ra, [ohm-cm]) and the constant lambda (λ)?
I found the equation: λ = (sqrt((Rm*d)/Ra))/2 (source: http://www.columbia.edu/cu/biology/cour ... cture5.pdf)
Hence: Ra = (Rm*diameter)/(4*(λ^2)).
Is this legit to use like that? Can one alter it via another property maybe?
Thank you very much!
Best,