action potectial amplitude
Posted: Wed Dec 17, 2008 12:23 am
Hi,
Consider a simple single compartment model with inserted "hh" mechanism. Then, for a given amplitude of current clamp model generates several action potential for a specific set of geometry, passive and active property. (assume model generate 4 spikes and action potential amplitude is around +40 mV).However, when some parameters in the model are changed, still model generates a firing pattern but maximum amplitude of AP changes dramatically and for example it finds a value equal to 0 mV.
I thought when model fires an action potential its amplitude has to be constant during firing pattern and even for different set of model parameters.
run the code . you will get 6 spike: maximum amplitude of first spike is ~39mV and other ~28mV, why difference between first and other spikes amplitude?
and if for example you changed the A.diam=1 you will get more spike (cause of higher input resistance ) but maximum amplitude of first spike is ~42mV and other ~0 mV. Why such a big difference amplitude between these two case?
Consider a simple single compartment model with inserted "hh" mechanism. Then, for a given amplitude of current clamp model generates several action potential for a specific set of geometry, passive and active property. (assume model generate 4 spikes and action potential amplitude is around +40 mV).However, when some parameters in the model are changed, still model generates a firing pattern but maximum amplitude of AP changes dramatically and for example it finds a value equal to 0 mV.
I thought when model fires an action potential its amplitude has to be constant during firing pattern and even for different set of model parameters.
Code: Select all
create A
A {L=10 diam=10 insert hh }
// insert a current clamp (del= 200 dur =100 amp=0.02 )
and if for example you changed the A.diam=1 you will get more spike (cause of higher input resistance ) but maximum amplitude of first spike is ~42mV and other ~0 mV. Why such a big difference amplitude between these two case?