I'm optimizing a NMDA glycine channel. I have 4 curve responses at different Glycine concentrations. At the end of the optimization I get quite a good fit within the multipleRunfitter window. But when I try to run the same simulation outside the runFitter I get quite a different response: in particular inside runFitter I get a current peak around 20ms, while during a normal simulations I get ~2ms (which mean the rising time has not been optimized).
I posted all NEURON windows relative to a Glycine concentration of 100 here:
http://pg.photos.yahoo.com/ph/crepatas/ ... cb&.src=ph
In particulat CI.jpg should have the same form as the black curve in OPT.jpg. (as you can see I set the correct value of c.gly at 100 just like within the MultipleRunFitter)