HCN channels modulation by cAMP
Posted: Wed Mar 01, 2017 6:01 am
Dear modelers,
I am very interested in having the (deterministic) HCN channels of my neruon modulated by [cAMP] however, I didn't find lots of information about this topic. To my knowledge, the only related post in this forum is this -viewtopic.php?f=18&t=3025-, and it didn't generate that much participation. I understand that the first step is to obtain a mathematical description of the phenomenon. After reading this paper -http://www.nature.com/nature/journal/v4 ... 805a0.html- I understood that -probably- the most interesting process to be captured in mathematical equations is the dependency on [cAMP] of the V_1/2 (half-activation voltage) of the Ih mechanism. I didn't find any satisfactory way for obtaining such equations (the only math present in the paper is mostly structural modeling of molecules).
Am I wrong? Perhaps the mentioned modulatory process has already been modelled and I missed it?
If not, I think that the modelers community could benefit a lot from a first NEURON(R) implementation of this modulation.
I am willing to start struggling with it:
Can anybody provide me with some primary material?
Best wishes,
mart
I am very interested in having the (deterministic) HCN channels of my neruon modulated by [cAMP] however, I didn't find lots of information about this topic. To my knowledge, the only related post in this forum is this -viewtopic.php?f=18&t=3025-, and it didn't generate that much participation. I understand that the first step is to obtain a mathematical description of the phenomenon. After reading this paper -http://www.nature.com/nature/journal/v4 ... 805a0.html- I understood that -probably- the most interesting process to be captured in mathematical equations is the dependency on [cAMP] of the V_1/2 (half-activation voltage) of the Ih mechanism. I didn't find any satisfactory way for obtaining such equations (the only math present in the paper is mostly structural modeling of molecules).
Am I wrong? Perhaps the mentioned modulatory process has already been modelled and I missed it?
If not, I think that the modelers community could benefit a lot from a first NEURON(R) implementation of this modulation.
I am willing to start struggling with it:
Can anybody provide me with some primary material?
Best wishes,
mart