www.neuron.yale.edu

Thanks for the reply.

What if I use an unmyelinated axon and instead of varying properties over sections, I aim to vary properties over segments ? Or should I use the distance function in that case ?

Mohit

Hi, I understand resistivity is a section variable and is constant over an entire section. https://www.neuron.yale.edu/neuron/static/docs/help/neuron/neuron/geometry.html#Ra I wanted to know if its possible to make resistivity dependent on the axon length. Eg: If an axon has 500 nodes, the first 250...

Hi,

I was recently thinking about it again. In what way does the connect affects the electrical boundary between the two sections ?

Mohit

Hi, I am trying to set up a dynamic clamp by importing a series of time varying stimulating currents as a matrix and playing them in VecStim.play. On plotting the stimulation currents, I get a plot consisting of all zeros. Here is the code snippet I am using in Python. current = np.genfromtxt('i.csv...

Thanks a lot for the reply.

Mohit

Hi ! I am trying to model the behaviour of squid giant axon at different temperature and using the results of this paper as a basis. (http://www.ncbi.nlm.nih.gov/pubmed/11081712). It reports the value of ~57mV at 5 oC and about -59 mV at 15oC. These values are different (more positive) than the stan...

Hi ! Thanks for the reply. I just ran a quick and dirty simulation. It works for the standard HH model. However, I am working with a model where I change the maximum conductances (to both Na and K ions) with temperature. However, as I keep reducing axon diameter, I start getting spontaneous activity...

Hi ! I want to ask a confirmation question. If I change the diameter of the axon (reduce it 10 times) in a squid giant axon model, do I need to change the maximum ionic conductance (gNabar, gKbar) accordingly. I would assume not, since the units of maximum conductance are in S/cm2 and would be taken...

Thanks for the response.

Mohit

Great ! That solved the modlunit issue. I am just curious, what does the symbol "?" mean in the .mod file? Like '? interface', or '? currents' etc ?

Thanks,

Mohit

Thanks for your reply. Indeed, there was an error. Ik should be ik = gk*pow(n,4)*(v)*(exp(v/24)-ko/ki)/(exp(v/24)-1) where v is the membrane voltage and ko is the external potassium concentration (in the periaxonal space). I modified the USEION statement to USEION k READ ki,ko WRITE ik. The mechanis...

Hi I am trying to reproduce the results of the paper " Excitability of the squid giant axon revisited. J Clay (1998)" (http://www.ncbi.nlm.nih.gov/pubmed/9705477). It has a modified version of the K current where Ik = gk*n^4*V*[exp(v/24)-ks/ki]/[exp(v/24)-1], where ks is the potassium conc...

I am trying to reproduce the results of the Sangrey et. al. 2004 paper (Analysis of the Optimal Channel Density of the Squid Giant Axon Using a Reparametrized Hodgkin-Huxley Model). In addition to changing the exponent of potassium activation factor n from 4 to 6, they also incorporated a gating cur...

Hi I am curious to know how does the 'connect' function in neuron work ? How does it account for changes if there are two different mechanisms inserted at either end of the junction between the two sections ( or when there are different parameters assigned eg, gKmax, temperature etc) Thanks, Mohit

Hi
I am not sure about this but off the top of my head, the conductance in the passive mechanism consists of the leak conductance from the HH mechanism plus the minor conductance from the movement of non specific ions.

Mohit